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№ 032

GHRP-2 / GHRP-6

Older growth-hormone boosters and the predecessors to Ipamorelin. These GH secretagogues split two ways: GHRP-2 is the cleaner, GHRP-6 brings stronger appetite stimulation.

GH-axis
Evidence: Limited

GHRP-2 / GHRP-6: Older growth-hormone boosters and the predecessors to Ipamorelin. These GH secretagogues split two ways: GHRP-2 is the cleaner, GHRP-6 brings stronger appetite stimulation. GHRP-2 and GHRP-6 are older GH-axis peptides, the predecessors to Ipamorelin.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
100-300 mcg sub-q
Half-life ⓘ
~15-30 minutes
Route ⓘ
Subcutaneous
Schedule
1-3x daily
In plain English

GHRP-2 and GHRP-6 are older GH-axis peptides, the predecessors to Ipamorelin. They tell your body to release more growth hormone, but with rougher side effects (cortisol bumps for GHRP-2, big appetite spikes for GHRP-6). Most people now run Ipamorelin instead, but these are cheap and well-studied.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved.

Compounding ⓘ
Category 2

FDA flagged as significant safety risk; restricted from compounding pharmacies.

WADA ⓘ
Banned (S2)
Prescribed ⓘ

Not prescribed in conventional medicine.

Who it's for

  • →Users wanting older, well-characterized GH secretagogues
  • →GHRP-6 specifically: people in a bulk who want appetite stimulation
  • →GHRP-2: cleaner profile users who tolerate cortisol bumps

What to expect

  1. Week 1

    GH pulse and (with GHRP-6) appetite kick within hours of first dose.

  2. Week 4

    Cumulative recovery and sleep improvements. Bulkers see appetite-driven gains.

  3. Week 8

    IGF-1 measurably higher. Receptor desensitization starting, cycle off soon.

Looking at GHRP-2 / GHRP-6? Your next 3 steps

  1. 1Work out your syringe units

    Vial size + BAC water turns into the exact units to draw for GHRP-2 / GHRP-6.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Hexapeptide GH secretagogues that activate the ghrelin receptor (GHS-R1a). GHRP-2 has cleaner signaling than GHRP-6 but less appetite stimulation; GHRP-6 retains stronger ghrelin-mimetic effects on hunger.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01GHRP-6: aggressive hunger 30-60 min post-dose
02GHRP-2: cortisol and prolactin bumps
03Head-rush at injection
04Receptor desensitization with chronic use

When NOT to use

  • ⚠Active malignancy
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • IGF-1 baseline + week 8
  • • Prolactin if running >8 weeks (GHRP-2)

Common mistakes

  • • Treating them as Ipamorelin equivalents, they have meaningful side effect differences
  • • Eating within 30 min of injection (kills the GH pulse)
  • • Skipping cycle breaks

Community patterns

Members only
Free, no account needed

New to GHRP-2 / GHRP-6? Grab the starter checklist.

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AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about GHRP-2 / GHRP-6 or your own stack. This is it working.

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Frequently asked

What is GHRP-2 / GHRP-6?+
GHRP-2 and GHRP-6 are older GH-axis peptides, the predecessors to Ipamorelin. They tell your body to release more growth hormone, but with rougher side effects (cortisol bumps for GHRP-2, big appetite spikes for GHRP-6). Most people now run Ipamorelin instead, but these are cheap and well-studied.
Is GHRP-2 / GHRP-6 FDA approved?+
Not FDA approved.
Is GHRP-2 / GHRP-6 legal?+
GHRP-2 / GHRP-6 is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is GHRP-2 / GHRP-6 banned by WADA?+
GHRP-2 / GHRP-6 is on the WADA prohibited list under Banned (S2).
Are you still natty after taking GHRP-2 / GHRP-6?+
No. GHRP-2 / GHRP-6 is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe GHRP-2 / GHRP-6?+
Not prescribed in conventional medicine.
What's the typical dose of GHRP-2 / GHRP-6?+
Dosing depends on your goal, experience, and tolerance. The full GHRP-2 / GHRP-6 protocol (dose, frequency, and how to titrate) is in the members section on the entry page.
What are the side effects of GHRP-2 / GHRP-6?+
Common side effects include: GHRP-6: aggressive hunger 30-60 min post-dose; GHRP-2: cortisol and prolactin bumps; Head-rush at injection; Receptor desensitization with chronic use. Less common effects and full safety details are on the entry page.
How long until GHRP-2 / GHRP-6 starts working?+
GH pulse and (with GHRP-6) appetite kick within hours of first dose.
What can you stack with GHRP-2 / GHRP-6?+
GHRP-2 / GHRP-6 is commonly combined with complementary compounds. The full stacking protocol (what to pair, dosing, and timing) is in the members section on the entry page.
Where do people get GHRP-2 / GHRP-6?+
Pepdex does not sell, ship, or recommend suppliers. GHRP-2 / GHRP-6 is not FDA-approved; prescription versions require licensed clinical care, and "research only" markets carry real legal and quality risks. /coa explains how to verify a Certificate of Analysis and /guides/scam-vendor-spotting covers the red flags.

More in GH-axis

№ 022
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№ 012
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Oral ghrelin mimetic. Bumps GH and IGF-1 without injections. Strong appetite stimulation is the trade-off.

№ 007
Ipamorelin

Bumps your natural growth-hormone pulses without hitting cortisol or prolactin. A selective GH secretagogue.

№ 008
CJC-1295 (no DAC)

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