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№ 012

MK-677 (Ibutamoren)

Oral ghrelin mimetic. Bumps GH and IGF-1 without injections. Strong appetite stimulation is the trade-off.

GH-axis
Evidence: Moderate

MK-677 (Ibutamoren): Oral ghrelin mimetic. Bumps GH and IGF-1 without injections. Strong appetite stimulation is the trade-off. MK-677 is the only oral GH-axis compound that actually works.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
10-25 mg orally
Half-life ⓘ
~24 hours
Route ⓘ
Oral
Schedule
Once daily
In plain English

MK-677 is the only oral GH-axis compound that actually works. It tricks your body into thinking it's hungry, which signals more GH release. Big appetite increase is the trade-off, great in a bulk, awful in a cut.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved. Reached Phase 2 trials, never approved.

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Banned (S2)
Prescribed ⓘ

Not prescribed in conventional medicine. Sometimes offered by anti-aging clinics off-label.

Before you start

Wear a CGM the first 14 days.

Known glucose-elevating effect; monitor or skip. A two-week sensor (~$80, OTC, no prescription) tells you more about how YOUR body is responding to MK-677 (Ibutamoren) than any protocol guide can. Most users wear one and don't again. The first cycle is the one that matters.

Get a CGM →

Who it's for

  • →Users who want GH benefits but won't inject
  • →People in a bulking / mass-gain phase
  • →Sleep-quality focused stacks

What to expect

  1. Week 1

    Sharp appetite increase. Vivid dreams, deeper sleep.

  2. Week 4

    Visible water retention, slight bloat. IGF-1 climbing.

  3. Week 8

    Recovery and body comp shifts in users training hard.

Looking at MK-677 (Ibutamoren)? Your next 3 steps

  1. 1Work out your syringe units

    Vial size + BAC water turns into the exact units to draw for MK-677 (Ibutamoren).

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

    A free account saves your stack; membership adds the stack-aware AI Coach.

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How it works (mechanism)

Oral non-peptide ghrelin-receptor agonist. Mimics ghrelin's signal to release GH and IGF-1. The same ghrelin signal also drives strong appetite stimulation, the trade-off of an oral GH-axis tool.

Dosing protocol

Members only

Stacks well with

Members only

Stack essentials

Members only

Side effects

01Aggressive appetite stimulation
02Water retention / bloat
03Numb/tingling hands (carpal-tunnel-like)
04Insulin resistance creeping up over long use
05Lethargy at higher doses

When NOT to use

  • ⚠Active malignancy
  • ⚠Pre-diabetic or insulin-resistant baseline
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • IGF-1 baseline + week 8
  • • Fasting glucose / insulin every 8 weeks

Common mistakes

  • • Running it during a cut (the appetite makes the cut nearly impossible)
  • • Stacking with anything that raises insulin resistance further
  • • Skipping cycle breaks

Drug & supplement interactions

  • ⚠Cortisol may bump slightly, caution if on glucocorticoid therapy
  • ⚠Insulin sensitivity may decrease over time, diabetics monitor closely
  • ⚠Strong appetite stimulation interferes with caloric-deficit goals

Community patterns

Members only
Free, no account needed

New to MK-677 (Ibutamoren)? Grab the starter checklist.

Drop your email and we'll send the one-page starter checklist beginners actually need first. No account needed.

No spam, and we never sell your email. Just the checklist. Email support@pepdex.co to opt out any time.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about MK-677 (Ibutamoren) or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is MK-677 (Ibutamoren)?+
MK-677 is the only oral GH-axis compound that actually works. It tricks your body into thinking it's hungry, which signals more GH release. Big appetite increase is the trade-off, great in a bulk, awful in a cut.
Is MK-677 (Ibutamoren) FDA approved?+
Not FDA approved. Reached Phase 2 trials, never approved.
Is MK-677 (Ibutamoren) legal?+
MK-677 (Ibutamoren) is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is MK-677 (Ibutamoren) banned by WADA?+
MK-677 (Ibutamoren) is on the WADA prohibited list under Banned (S2).
Are you still natty after taking MK-677 (Ibutamoren)?+
No. MK-677 (Ibutamoren) is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe MK-677 (Ibutamoren)?+
Not prescribed in conventional medicine. Sometimes offered by anti-aging clinics off-label.
What's the typical dose of MK-677 (Ibutamoren)?+
Dosing depends on your goal, experience, and tolerance. The full MK-677 (Ibutamoren) protocol (dose, frequency, and how to titrate) is in the members section on the entry page.
What are the side effects of MK-677 (Ibutamoren)?+
Common side effects include: Aggressive appetite stimulation; Water retention / bloat; Numb/tingling hands (carpal-tunnel-like); Insulin resistance creeping up over long use. Less common effects and full safety details are on the entry page.
How long until MK-677 (Ibutamoren) starts working?+
Sharp appetite increase. Vivid dreams, deeper sleep.
What can you stack with MK-677 (Ibutamoren)?+
MK-677 (Ibutamoren) is commonly combined with complementary compounds. The full stacking protocol (what to pair, dosing, and timing) is in the members section on the entry page.
Where do people get MK-677 (Ibutamoren)?+
Pepdex does not sell, ship, or recommend suppliers. MK-677 (Ibutamoren) is not FDA-approved; prescription versions require licensed clinical care, and "research only" markets carry real legal and quality risks. /coa explains how to verify a Certificate of Analysis and /guides/scam-vendor-spotting covers the red flags.
MK-677 (Ibutamoren) vs Ipamorelin, which is better?+
MK-677 vs Ipamorelin: oral vs injectable GH-axis support, with side effect and tolerance trade-offs. Full head-to-head comparison: https://pepdex.co/compare/mk-677-vs-ipamorelin
MK-677 (Ibutamoren) vs HGH (Somatropin), which is better?+
HGH vs MK-677: actual growth hormone vs an oral secretagogue. Legal, mechanism, and risk differences. Full head-to-head comparison: https://pepdex.co/compare/hgh-vs-mk-677

Head-to-head with MK-677 (Ibutamoren)

Compare
MK-677 (Ibutamoren) vs Ipamorelin →
Compare
MK-677 (Ibutamoren) vs HGH (Somatropin) →

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