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№ 033

Kisspeptin-10

Kick-starts your body's own testosterone production at the very top. It sits upstream of the entire HPG axis, triggering the natural cascade of GnRH → LH → testosterone, a different lever than the melanocortin libido peptides.

Libido
Evidence: Moderate

Kisspeptin-10: Kick-starts your body's own testosterone production at the very top. It sits upstream of the entire HPG axis, triggering the natural cascade of GnRH → LH → testosterone, a different lever than the melanocortin libido peptides. Kisspeptin sits at the very top of the chain that produces testosterone.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
25-100 mcg sub-q
Half-life ⓘ
~4 minutes (kisspeptin-10)
Route ⓘ
Subcutaneous
Schedule
As needed or 1-2x daily during a short cycle
In plain English

Kisspeptin sits at the very top of the chain that produces testosterone. When you inject it, your body's own testosterone-making cascade fires off naturally. It's a different lever than PT-141, kisspeptin is upstream hormones, PT-141 is melanocortin pathway.

Status & legalityWhat do these mean? →
Natty? ⓘ
Grey area

Modulates your own HPG axis rather than introducing exogenous testosterone, but federations differ.

FDA ⓘ
Not approved

Not FDA approved. In clinical investigation for fertility / HPG-axis applications.

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Banned (S2)

Explicitly named on the 2026 WADA Prohibited List under S2.2.1 (testosterone-stimulating peptides), prohibited in male athletes at all times. Not restricted in female athletes.

Prescribed ⓘ

Used in some fertility-medicine research contexts.

Who it's for

  • →Users with low LH / suppressed HPG axis post-cycle
  • →Fertility-adjacent contexts under medical guidance
  • →Researchers exploring HPG-axis modulation

What to expect

  1. Week 1

    LH and testosterone bumps within hours of dose. Subjective libido response varies.

  2. Week 4

    If on a short course, complete it. Effects don't compound the way they do with daily peptides.

  3. Week 8

    Off-cycle.

Looking at Kisspeptin-10? Your next 3 steps

  1. 1Work out your syringe units

    Vial size + BAC water turns into the exact units to draw for Kisspeptin-10.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Activates the kisspeptin receptor (KISS1R / GPR54) on hypothalamic neurons. The most upstream signal in the HPG axis, kisspeptin tells the hypothalamus to release GnRH, which tells the pituitary to release LH/FSH, which drives gonadal testosterone production.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Generally well tolerated
02Mild headache rarely
03Brief facial flush

When NOT to use

  • ⚠Pregnancy
  • ⚠Active reproductive cancer

Bloodwork to monitor

  • • LH, FSH, total testosterone if running for HPG-axis purposes

Common mistakes

  • • Treating it like PT-141 (different mechanism, kisspeptin is upstream HPG, PT-141 is melanocortin)
  • • Running it chronically
  • • Stacking with multiple HPG modulators without monitoring

Drug & supplement interactions

  • ⚠Hormone-modulating drugs (TRT, GnRH agonists/antagonists, oral contraceptives) all interact with the HPG axis kisspeptin sits at the top of
  • ⚠Use under provider guidance if you're on any HPG-axis medication
Free, no account needed

New to Kisspeptin-10? Grab the starter checklist.

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AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Kisspeptin-10 or your own stack. This is it working.

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Frequently asked

What is Kisspeptin-10?+
Kisspeptin sits at the very top of the chain that produces testosterone. When you inject it, your body's own testosterone-making cascade fires off naturally. It's a different lever than PT-141, kisspeptin is upstream hormones, PT-141 is melanocortin pathway.
Is Kisspeptin-10 FDA approved?+
Not FDA approved. In clinical investigation for fertility / HPG-axis applications.
Is Kisspeptin-10 legal?+
Kisspeptin-10 is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is Kisspeptin-10 banned by WADA?+
Kisspeptin-10 is on the WADA prohibited list under Banned (S2). Explicitly named on the 2026 WADA Prohibited List under S2.2.1 (testosterone-stimulating peptides), prohibited in male athletes at all times. Not restricted in female athletes.
Are you still natty after taking Kisspeptin-10?+
Grey area. Modulates your own HPG axis rather than introducing exogenous testosterone, but federations differ.
Do doctors prescribe Kisspeptin-10?+
Used in some fertility-medicine research contexts.
What's the typical dose of Kisspeptin-10?+
Dosing depends on your goal, experience, and tolerance. The full Kisspeptin-10 protocol (dose, frequency, and how to titrate) is in the members section on the entry page.
What are the side effects of Kisspeptin-10?+
Common side effects include: Generally well tolerated; Mild headache rarely; Brief facial flush. Less common effects and full safety details are on the entry page.
How long until Kisspeptin-10 starts working?+
LH and testosterone bumps within hours of dose. Subjective libido response varies.
What can you stack with Kisspeptin-10?+
Kisspeptin-10 is commonly combined with complementary compounds. The full stacking protocol (what to pair, dosing, and timing) is in the members section on the entry page.
Where do people get Kisspeptin-10?+
Pepdex does not sell, ship, or recommend suppliers. Kisspeptin-10 is not FDA-approved; prescription versions require licensed clinical care, and "research only" markets carry real legal and quality risks. /coa explains how to verify a Certificate of Analysis and /guides/scam-vendor-spotting covers the red flags.
Kisspeptin-10 vs PT-141 (Bremelanotide), which is better?+
PT-141 vs Kisspeptin for libido: melanocortin pathway vs upstream HPG axis. Two different mechanisms, different use cases. Full head-to-head comparison: https://pepdex.co/compare/pt-141-vs-kisspeptin

Head-to-head with Kisspeptin-10

Compare
Kisspeptin-10 vs PT-141 (Bremelanotide) →

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