pepdex
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№ 002

TB-500

A fragment of Thymosin Beta-4. Drives cell migration and tissue repair, used for chronic soft-tissue stuff.

Healing
Evidence: Limited
Half-life
~2-3 days
Route
Subcutaneous or intramuscular
Cycle
8-12 weeks total
Schedule
Loading 2x/wk → maintenance 1x/wk
In plain English

TB-500 is a fragment of a natural healing protein your body already makes. It's used for chronic injuries that won't resolve on their own — old shoulder issues, lingering tendon pain. You usually pair it with BPC-157 for a stronger combined effect.

Status & legality
Natty?
Not natty
FDA
Not approved

Not FDA approved for any indication.

Compounding
Category 1

Compounding pharmacies may prepare under physician prescription (post Feb 2026 reclassification, pending formal FDA publication).

WADA
Banned (S2)
Prescribed

Not prescribed in conventional medicine.

Who it's for

  • →Anyone with a chronic soft-tissue injury that won't resolve
  • →Lifters running BPC-157 for synergy
  • →Athletes in connective-tissue recovery phases

What to expect

  1. Week 1

    Mild fatigue first few days from the loading phase.

  2. Week 4

    Loading phase ends. Most users feel the underlying injury settling.

  3. Week 8

    Maintenance phase. Cumulative effect on chronic tissue.

Dosing protocol

Loading: 2-2.5mg twice weekly for 4-6 weeks. Maintenance: 2-2.5mg weekly for 4-8 weeks.

Stacks well with

BPC-157 (the canonical healing stack)

Side effects

01Mild fatigue during loading
02Injection-site soreness
03Brief head-rush at injection

When NOT to use

  • ⚠Active malignancy
  • ⚠Pregnancy / nursing (no data)

Common mistakes

  • • Skipping the loading phase, then wondering why nothing happened
  • • Stopping at 4 weeks instead of completing the full cycle
  • • Storing reconstituted vials at room temp instead of refrigerated

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is TB-500?+
TB-500 is a fragment of a natural healing protein your body already makes. It's used for chronic injuries that won't resolve on their own — old shoulder issues, lingering tendon pain. You usually pair it with BPC-157 for a stronger combined effect.
Is TB-500 FDA approved?+
Not FDA approved for any indication.
Is TB-500 banned by WADA?+
TB-500 is on the WADA prohibited list under Banned (S2).
Are you still natty after taking TB-500?+
No. TB-500 is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe TB-500?+
Not prescribed in conventional medicine.
What's the typical dose of TB-500?+
Loading: 2-2.5mg twice weekly for 4-6 weeks. Maintenance: 2-2.5mg weekly for 4-8 weeks.
What are the side effects of TB-500?+
Common side effects include: Mild fatigue during loading; Injection-site soreness; Brief head-rush at injection. Less common effects and full safety details are on the entry page.
How long until TB-500 starts working?+
Mild fatigue first few days from the loading phase.