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№ 001

BPC-157

Synthetic peptide derived from a stomach protein. Used to speed up tendon, ligament, and gut healing.

Healing
Evidence: Limited

BPC-157: Synthetic peptide derived from a stomach protein. Used to speed up tendon, ligament, and gut healing. Think of BPC-157 as a healing accelerator for connective tissue.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
200-500 mcg sub-q daily
Half-life ⓘ
~4 hours sub-q
Route ⓘ
Subcutaneous (oral for gut)
Schedule
Daily
In plain English

Think of BPC-157 as a healing accelerator for connective tissue. Most users run it for stubborn tendon, ligament, or gut problems where regular rehab has stalled. You inject a tiny amount under the skin once a day for 4-6 weeks, take a break, then reassess.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty

Synthetic performance-enhancing peptide. Tested athletes will fail.

FDA ⓘ
Not approved

Not FDA approved for any indication.

Compounding ⓘ
Category 1

Compounding pharmacies may prepare under physician prescription (post Feb 2026 reclassification, pending formal FDA publication).

WADA ⓘ
Banned (S0 – Non-Approved)

Added to WADA's S0 'Non-Approved Substances' list in 2022.

Prescribed ⓘ

Not prescribed in conventional medicine. Some compounding pharmacies and longevity clinics offer it off-label.

Who it's for

  • →Lifters with nagging tendon or joint pain
  • →Anyone recovering from a soft-tissue injury
  • →People dealing with gut issues (oral form)

What to expect

  1. Week 1

    Often nothing yet, sometimes mild head-rush at injection.

  2. Week 4

    Most users notice the original injury feels notably less reactive.

  3. Week 8

    Full effect for the cycle. Plateau, then take a break.

Looking at BPC-157? Your next 3 steps

  1. 1Work out your syringe units

    Vial size + BAC water turns into the exact units to draw for BPC-157.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Promotes angiogenesis (new blood vessel growth) and accelerates fibroblast / endothelial cell migration to injury sites. Also modulates the nitric oxide pathway and protects against gut-wall damage. Most effects appear at the local injection site rather than systemically.

Dosing protocol

Members only

Stacks well with

Members only

Stack essentials

Members only

Side effects

01Mild injection-site irritation
02Lightheadedness in first few doses
03Transient appetite changes

When NOT to use

  • ⚠Active malignancy (theoretical)
  • ⚠Pregnancy / nursing (no data)

Common mistakes

  • • Running it indefinitely instead of cycling
  • • Underdosing (under 200mcg often blunts the response)
  • • Leaving reconstituted vial at room temp longer than 7 days

Drug & supplement interactions

  • ⚠Limited documented drug interactions
  • ⚠Some users report compounded effect with NSAIDs (no published data)
  • ⚠Theoretical caution with pro-angiogenic compounds in malignancy contexts

The Pepdex take

Pepdex take: 250mcg/day for 5 weeks is the sweet spot for chronic shoulder. Minor change by week 3, real change by week 5. Bilateral injection near the joint outperforms distal abdominal injection in community reports, the local-injection question is still debated in the literature, but for tendon work, near-the-injury wins for most users. Don't bother running below 200mcg, it doesn't crack the threshold reliably.

Community patterns

Members only
Free, no account needed

New to BPC-157? Grab the starter checklist.

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AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about BPC-157 or your own stack. This is it working.

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Frequently asked

What is BPC-157?+
Think of BPC-157 as a healing accelerator for connective tissue. Most users run it for stubborn tendon, ligament, or gut problems where regular rehab has stalled. You inject a tiny amount under the skin once a day for 4-6 weeks, take a break, then reassess.
Is BPC-157 FDA approved?+
Not FDA approved for any indication.
Is BPC-157 legal?+
BPC-157 is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is BPC-157 banned by WADA?+
BPC-157 is on the WADA prohibited list under Banned (S0 – Non-Approved). Added to WADA's S0 'Non-Approved Substances' list in 2022.
Are you still natty after taking BPC-157?+
No. Synthetic performance-enhancing peptide. Tested athletes will fail.
Do doctors prescribe BPC-157?+
Not prescribed in conventional medicine. Some compounding pharmacies and longevity clinics offer it off-label.
What's the typical dose of BPC-157?+
Dosing depends on your goal, experience, and tolerance. The full BPC-157 protocol (dose, frequency, and how to titrate) is in the members section on the entry page.
What are the side effects of BPC-157?+
Common side effects include: Mild injection-site irritation; Lightheadedness in first few doses; Transient appetite changes. Less common effects and full safety details are on the entry page.
How long until BPC-157 starts working?+
Often nothing yet, sometimes mild head-rush at injection.
What can you stack with BPC-157?+
BPC-157 is commonly combined with complementary compounds. The full stacking protocol (what to pair, dosing, and timing) is in the members section on the entry page.
Where do people get BPC-157?+
Pepdex does not sell, ship, or recommend suppliers. BPC-157 is not FDA-approved; prescription versions require licensed clinical care, and "research only" markets carry real legal and quality risks. /coa explains how to verify a Certificate of Analysis and /guides/scam-vendor-spotting covers the red flags.
BPC-157 vs TB-500, which is better?+
BPC-157 vs TB-500 for healing: which to pick, and why most users run them together as the canonical healing stack. Full head-to-head comparison: https://pepdex.co/compare/bpc-157-vs-tb-500
BPC-157 vs GHK-Cu, which is better?+
BPC-157 vs GHK-Cu: tendon and tissue healing vs collagen and skin support. Which to pick or whether to stack. Full head-to-head comparison: https://pepdex.co/compare/bpc-157-vs-ghk-cu

Head-to-head with BPC-157

Compare
BPC-157 vs TB-500 →
Compare
BPC-157 vs GHK-Cu →

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