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№ 056

PNC-27

Membranolytic peptide that selectively kills cancer cells expressing HDM-2 (oncoprotein) on the membrane surface. Pre-clinical anti-cancer research compound.

Immune
Evidence: Anecdotal

PNC-27: Membranolytic peptide that selectively kills cancer cells expressing HDM-2 (oncoprotein) on the membrane surface. Pre-clinical anti-cancer research compound. PNC-27 is a peptide that punches holes in cancer-cell membranes by binding HDM-2, an oncoprotein found on tumor cell surfaces.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
No standardized human dose
Half-life ⓘ
~hours
Route ⓘ
Subcutaneous or IV (research)
Schedule
Daily in research protocols
In plain English

PNC-27 is a peptide that punches holes in cancer-cell membranes by binding HDM-2, an oncoprotein found on tumor cell surfaces. Healthy cells don't express HDM-2 on the surface, so it's selective in theory. Pre-clinical research compound, not approved for treatment.

Status & legalityWhat do these mean? →
Natty? ⓘ
Grey area

Anti-cancer peptide. Federations don't typically address research compounds.

FDA ⓘ
Not approved

Not FDA approved. Pre-clinical research compound.

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Not listed
Prescribed ⓘ

Not prescribed in conventional medicine outside research contexts.

Who it's for

  • →Cancer-research contexts under medical oversight
  • →Educational reference, pre-clinical only
  • →Compassionate-use research scenarios

What to expect

  1. Week 1

    Acute responses in animal/cell models.

  2. Week 4

    Pre-clinical endpoint.

  3. Week 8

    No human long term safety data.

Looking at PNC-27? Your next 3 steps

  1. 1Work out your syringe units

    Vial size + BAC water turns into the exact units to draw for PNC-27.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Membranolytic peptide. Selectively binds HDM-2 (an oncoprotein) found on the membrane surface of cancer cells (rarely on healthy cells), then lyses the cell membrane. Pre-clinical anti-cancer mechanism.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Limited human safety data
02Theoretical off-target membrane effects
03Injection-site reaction

When NOT to use

  • ⚠Anyone without medical oversight
  • ⚠Pregnancy / nursing
  • ⚠Active autoimmune conditions

Bloodwork to monitor

  • • CBC, CMP, LFTs at minimum if researching

Common mistakes

  • • Self-administering for cancer treatment (this is pre-clinical, not approved)
  • • Skipping medical oversight
  • • Long cycles without safety monitoring
Free, no account needed

New to PNC-27? Grab the starter checklist.

Drop your email and we'll send the one-page starter checklist beginners actually need first. No account needed.

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AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about PNC-27 or your own stack. This is it working.

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Frequently asked

What is PNC-27?+
PNC-27 is a peptide that punches holes in cancer-cell membranes by binding HDM-2, an oncoprotein found on tumor cell surfaces. Healthy cells don't express HDM-2 on the surface, so it's selective in theory. Pre-clinical research compound, not approved for treatment.
Is PNC-27 FDA approved?+
Not FDA approved. Pre-clinical research compound.
Is PNC-27 legal?+
PNC-27 is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is PNC-27 banned by WADA?+
PNC-27 is not currently on the WADA prohibited list.
Are you still natty after taking PNC-27?+
Grey area. Anti-cancer peptide. Federations don't typically address research compounds.
Do doctors prescribe PNC-27?+
Not prescribed in conventional medicine outside research contexts.
What's the typical dose of PNC-27?+
Dosing depends on your goal, experience, and tolerance. The full PNC-27 protocol (dose, frequency, and how to titrate) is in the members section on the entry page.
What are the side effects of PNC-27?+
Common side effects include: Limited human safety data; Theoretical off-target membrane effects; Injection-site reaction. Less common effects and full safety details are on the entry page.
How long until PNC-27 starts working?+
Acute responses in animal/cell models.
What can you stack with PNC-27?+
PNC-27 is commonly combined with complementary compounds. The full stacking protocol (what to pair, dosing, and timing) is in the members section on the entry page.
Where do people get PNC-27?+
Pepdex does not sell, ship, or recommend suppliers. PNC-27 is not FDA-approved; prescription versions require licensed clinical care, and "research only" markets carry real legal and quality risks. /coa explains how to verify a Certificate of Analysis and /guides/scam-vendor-spotting covers the red flags.

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