№ 035

Mazdutide

A weight-loss shot already approved in China. Innovent Biologics' GLP-1 + glucagon dual agonist out of China, with strong Phase 3 data and a 2025 China approval for obesity.

Fat Loss

Evidence: Moderate

Mazdutide: A weight-loss shot already approved in China. Innovent Biologics' GLP-1 + glucagon dual agonist out of China, with strong Phase 3 data and a 2025 China approval for obesity. Mazdutide is a Chinese-developed GLP-1 + glucagon dual agonist, same class as Survodutide and Retatrutide.

Fat Loss

Mazdutide reconstitutes clear. Set expectations.

FDA ⓘ

Not approved

WADA

Not banned

Typical dose

Start 3 mg weekly

Half-life ⓘ

~8 days (dose-dependent)

Route ⓘ

Subcutaneous

Schedule

Once weekly

In plain English

Mazdutide is a Chinese-developed GLP-1 + glucagon dual agonist, same class as Survodutide and Retatrutide. Approved in China in 2025 for obesity. The glucagon part adds a metabolic-rate bump on top of GLP-1's appetite suppression.

Status & legalityWhat do these mean? →

Natty? ⓘ

Not natty

FDA ⓘ

Not approved

Not FDA approved. Approved in China (2025, Innovent, brand Xinermei) for obesity and type 2 diabetes. Eli Lilly holds ex-China rights (LY-3305677) and runs US development (Phase 2).

Compounding ⓘ

Investigational

In clinical trials, not yet approved for prescription.

WADA ⓘ

Not listed

Prescribed ⓘ

Available by prescription in China. Not yet available in the US.

Who it's for

→Users wanting a GLP/glucagon agonist with cleaner side effect profile than Survodutide reports
→Followers of Chinese metabolic-drug development

What to expect

Week 1
Appetite drops. Mild nausea.
Week 4
First titration step. Modest weight loss.
Week 8
Cumulative loss tracking similar to Tirzepatide trajectory.

Looking at Mazdutide? Your next 3 steps

1Work out your syringe units
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2See what to stack & monitor
The companion supplements and the bloodwork worth tracking on this kind of protocol.
Bloodwork guide →
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How it works (mechanism)

GLP-1 + glucagon dual agonist developed in China. Same dual-receptor strategy as Survodutide.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Nausea

02Constipation or diarrhea

03Mild fatigue

04Slightly elevated heart rate (glucagon effect)

When NOT to use

⚠MTC / MEN-2 history
⚠Pancreatitis history
⚠Pregnancy / nursing

Bloodwork to monitor

• Lipid panel
• ALT/AST
• A1C

Common mistakes

• Treating it as freely available, it's only approved in China currently
• Titrating too fast
• Skipping protein during the cut

Drug & supplement interactions

⚠Insulin and sulfonylureas: dose reduction needed
⚠Glucagon arm: monitor HR
⚠Trial-only outside China, full US interaction profile not yet published

Community patterns

Members only

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AI Coach, live sample

Members only

is 250mcg of bpc enough for a knee injury?

For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.

how much bac water for a 10mg reta vial?

3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.

what should i track on bloodwork for tirzepatide?

Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Mazdutide or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is Mazdutide?+

Is Mazdutide FDA approved?+

Not FDA approved. Approved in China (2025, Innovent, brand Xinermei) for obesity and type 2 diabetes. Eli Lilly holds ex-China rights (LY-3305677) and runs US development (Phase 2).

Is Mazdutide legal?+

Mazdutide is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.

Is Mazdutide banned by WADA?+

Mazdutide is not currently on the WADA prohibited list.

Are you still natty after taking Mazdutide?+

No. Mazdutide is a performance-enhancing peptide and would disqualify a strict natty claim.

Do doctors prescribe Mazdutide?+

Available by prescription in China. Not yet available in the US.

What's the typical dose of Mazdutide?+

Dosing depends on your goal, experience, and tolerance. The full Mazdutide protocol (dose, frequency, and how to titrate) is in the members section on the entry page.

What are the side effects of Mazdutide?+

Common side effects include: Nausea; Constipation or diarrhea; Mild fatigue; Slightly elevated heart rate (glucagon effect). Less common effects and full safety details are on the entry page.

How long until Mazdutide starts working?+

Appetite drops. Mild nausea.

What can you stack with Mazdutide?+

Mazdutide is commonly combined with complementary compounds. The full stacking protocol (what to pair, dosing, and timing) is in the members section on the entry page.

Where do people get Mazdutide?+

Pepdex does not sell, ship, or recommend suppliers. Mazdutide is not FDA-approved; prescription versions require licensed clinical care, and "research only" markets carry real legal and quality risks. /coa explains how to verify a Certificate of Analysis and /guides/scam-vendor-spotting covers the red flags.

Mazdutide vs Retatrutide, which is better?+

How Mazdutide and Retatrutide compare on research category, evidence tier, regulatory status, and reported side effects. Full head-to-head comparison: https://pepdex.co/compare/mazdutide-vs-retatrutide

Mazdutide vs Survodutide, which is better?+

Mazdutide vs Survodutide: two late-stage GLP-1 + glucagon dual agonists. Innovent vs Boehringer Ingelheim development paths. Full head-to-head comparison: https://pepdex.co/compare/mazdutide-vs-survodutide

Mazdutide vs Semaglutide, which is better?+

Semaglutide vs Mazdutide: GLP-1 only vs GLP-1 + glucagon dual agonist. China-approved Mazdutide vs the global standard. Full head-to-head comparison: https://pepdex.co/compare/semaglutide-vs-mazdutide

Head-to-head with Mazdutide

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Mazdutide vs Retatrutide →

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Mazdutide vs Survodutide →

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Mazdutide vs Semaglutide →

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№ 009

Tirzepatide

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№ 010

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The original weight-loss wave, sold as Ozempic / Wegovy. A GLP-1 agonist.

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Triple agonist (GLP-1 + GIP + glucagon) from Eli Lilly. In trials it outperforms Tirzepatide for weight loss.

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Liraglutide (Saxenda / Victoza)

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