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№ 008

Tirzepatide

Dual agonist (GLP-1 + GIP). FDA-approved as Mounjaro / Zepbound. Strong weight loss with cleaner side effect profile than semaglutide.

Fat Loss
Half-life
~5 days
Route
Subcutaneous
Cycle
Open-ended, titrate over months
Schedule
Once weekly
In plain English

Tirzepatide is the prescription weight-loss drug sold as Mounjaro (diabetes) or Zepbound (weight loss). It hits two appetite-control receptors at once. Most users lose 15-20% of body weight over several months. One injection per week.

Status & legality
Natty?
Not natty

Body-comp drug. Most natty federations consider any prescription weight-loss drug disqualifying.

FDA
Approved

Approved as Mounjaro (2022, type 2 diabetes) and Zepbound (2023, obesity).

WADA
Not listed

GLP/GIP agonists are not currently classified as banned by WADA.

Prescribed

Yes — widely prescribed by primary care, endocrinologists, and obesity-medicine specialists.

Who it's for

  • →Users who couldn't tolerate semaglutide
  • →Metabolic-syndrome adults under provider guidance
  • →Long-term weight management

What to expect

  1. Week 1

    Appetite drops. Mild nausea common.

  2. Week 4

    First titration step. ~2-5lb down for most.

  3. Week 8

    Cumulative loss 5-10lb. Side effects taper.

Dosing protocol

Start 2.5mg weekly. Titrate by 2.5mg every 4 weeks. Common max 10-15mg.

Stacks well with

Standalone
MOTS-c during cuts

Side effects

01Nausea
02Constipation
03Reflux
04Fatigue
05Underrating protein intake

When NOT to use

  • ⚠MTC / MEN-2 history
  • ⚠Pancreatitis history
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Lipid panel
  • • ALT/AST
  • • A1C if relevant

Common mistakes

  • • Titrating too fast
  • • Not lifting / eating protein during the cut
  • • Stopping cold turkey without a maintenance plan

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is Tirzepatide?+
Tirzepatide is the prescription weight-loss drug sold as Mounjaro (diabetes) or Zepbound (weight loss). It hits two appetite-control receptors at once. Most users lose 15-20% of body weight over several months. One injection per week.
Is Tirzepatide FDA approved?+
Approved as Mounjaro (2022, type 2 diabetes) and Zepbound (2023, obesity).
Is Tirzepatide banned by WADA?+
Tirzepatide is not currently on the WADA prohibited list. GLP/GIP agonists are not currently classified as banned by WADA.
Are you still natty after taking Tirzepatide?+
No. Body-comp drug. Most natty federations consider any prescription weight-loss drug disqualifying.
Do doctors prescribe Tirzepatide?+
Yes — widely prescribed by primary care, endocrinologists, and obesity-medicine specialists.
What's the typical dose of Tirzepatide?+
Start 2.5mg weekly. Titrate by 2.5mg every 4 weeks. Common max 10-15mg.
What are the side effects of Tirzepatide?+
Common side effects include: Nausea; Constipation; Reflux; Fatigue. Less common effects and full safety details are on the entry page.
How long until Tirzepatide starts working?+
Appetite drops. Mild nausea common.